季泉江

海以南不再蓝
精选回答

2005年-2009年就读于南京大学化学系获得理学学士学位;2009年-2014年就读于芝加哥大学化学系,获得化学博士学位(导师为何川教授);2014年-2016年在加州大学伯克利分校化学系从事博士后研究(合作教授为Michelle Chang 教授);2016年2月加入上海科技大学物质科学和技术学院,任助理教授。曾经荣获2013年国家优秀自费留学生奖,Camille and Henry Dreyfus Postdoc Fellow, Everett E Gilbert Memorial Prize等奖项。
季泉江个人简介2005年-2009年就读于南京大学化学系获得理学学士学位;2009年-2014年就读于芝加哥大学化学系,获得化学博士学位(导师为何川教授);2014年-2016年在加州大学伯克利分校化学系从事博士后研究(合作教授为Michelle Chang 教授);2016年2月加入上海科技大学物质科学和技术学院,任助理教授。曾经荣获2013年国家优秀自费留学生奖,Camille and Henry Dreyfus Postdoc Fellow, Everett E Gilbert Memorial Prize等奖项。
季泉江研究内容研究组以当代社会所面临的能源,环境和健康等方面的重大问题为导向,利用合成生物学和化学生物学等手段,致力于下一代生物能源生产工程菌株,环境污染物富集或降解工程菌株的定向进化和相关进化技术的开发,以及重要人类致病菌致病机制探索与小分子药物开发等方面的研究。
20. Chen, W, Zhang, Y, Yeo, WS, Bae, T, Ji, Q. Rapid and efficient genome editing in Staphylococcus aureus by using an engineered CRISPR/Cas9 system. J Am Chem Soc DOI: 10.1021/jacs.6b13317 (2017).
19. Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signaling. Nat Cell Biol. 17, 1484-96 (2015).
18. Kang HB, Fan J, Lin R, Elf S, Ji Q, Zhao L, Jin L, Seo JH, Shan C, Arbiser JL, Cohen C, Brat D, Miziorko HM, Kim E, Abdel-Wahab O, Merghoub T, Fr?hling S, Scholl C, Tamayo P, Barbie DA, Zhou L, Pollack BP, Fisher K, Kudchadkar RR, Lawson DH, Sica G, Rossi M, Lonial S, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, He C, Kang S, Chen J. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Mol Cell. 59, 345-58 (2015).
17. Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C. Widespread occurrence of N6-methyladenosine in bacterial mRNA. Nucleic Acids Res. 43, 6557-67 (2015).
16. Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Doré LC, Weng X, Ji Q, Mets L, He C. N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell. 161, 879-92 (2015).
15. Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 55, 552-65 (2014).
14. Deng X, Liang H, Ulanovskaya OA, Ji Q, Zhou T, Sun F, Lu Z, Hutchison AL, Lan L, Wu M, Cravatt BF, He C. Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa. J Bacteriol. 196, 2499-513 (2014).
13. Chen W, Zhang L, Zheng G, Fu Y, Ji Q, Liu F, Chen H, He C. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 588, 892-8 (2014).
12. Ji Q, Zhao BS, He C. A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells. Chem Commun. 49, 8027-9 (2013).
11. Deng X, Weerapana E, Ulanovskaya O, Sun F, Liang H, Ji Q, Ye Y, Fu Y, Zhou L, Li J, Zhang H, Wang C, Alvarez S, Hicks LM, Lan L, Wu M, Cravatt BF, He C. Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host Microbe. 13, 358-70 (2013).
10. Ji Q, Zhang L, Jones MB, Sun F, Deng X, Liang H, Cho H, Brugarolas P, Gao YN, Peterson SN, Lan L, Bae T, He C. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci U S A. 110, 5010-5 (2013).
9. Liang H, Deng X, Bosscher M, Ji Q, Jensen MP, He C. Engineering bacterial two-component system PmrA/PmrB to sense lanthanide ions. J Am Chem Soc. 135, 2037-9 (2013).
8. Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L, He C. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 109, 15461-6 (2012).
7. Jeong DW, Cho H, Jones MB, Shatzkes K, Sun F, Ji Q, Liu Q, Peterson SN, He C, Bae T. The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus. Mol Microbiol. 86, 331-48 (2012).
6. Sun F, Liang H, Kong X, Xie S, Cho H, Deng X, Ji Q, Zhang H, Alvarez S, Hicks LM, Bae T, Luo C, Jiang H, He C. Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A. 109, 9095-100 (2012).
5. Ji Q, Zhang L, Sun F, Deng X, Liang H, Bae T, He C. Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response. J Biol Chem. 287, 21102-9 (2012).
4. Liang H, Deng X, Ji Q, Sun F, Shen T, He C. The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. J Bacteriol. 194, 3098-108 (2012).
3. Deng X, Sun F, Ji Q, Liang H, Missiakas D, Lan L, He C. Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus. J Bacteriol. 194, 1753-62 (2012).
2. Sun F, Ji Q, Jones MB, Deng X, Liang H, Frank B, Telser J, Peterson SN, Bae T, He C. AirSR, a
1. Ding L, Ji Q, Qian R, Cheng W, Ju H. Lectin-based nanoprobes functionalized with enzyme for highly sensitive electrochemical monitoring of dynamic carbohydrate expression on living cells. Anal Chem. 82, 1292-8 (2010).
季泉江代表论文20. Chen, W, Zhang, Y, Yeo, WS, Bae, T, Ji, Q. Rapid and efficient genome editing in Staphylococcus aureus by using an engineered CRISPR/Cas9 system. J Am Chem Soc DOI: 10.1021/jacs.6b13317 (2017).
19. Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signaling. Nat Cell Biol. 17, 1484-96 (2015).
18. Kang HB, Fan J, Lin R, Elf S, Ji Q, Zhao L, Jin L, Seo JH, Shan C, Arbiser JL, Cohen C, Brat D, Miziorko HM, Kim E, Abdel-Wahab O, Merghoub T, Fr?hling S, Scholl C, Tamayo P, Barbie DA, Zhou L, Pollack BP, Fisher K, Kudchadkar RR, Lawson DH, Sica G, Rossi M, Lonial S, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, He C, Kang S, Chen J. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Mol Cell. 59, 345-58 (2015).
17. Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C. Widespread occurrence of N6-methyladenosine in bacterial mRNA. Nucleic Acids Res. 43, 6557-67 (2015).
16. Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Doré LC, Weng X, Ji Q, Mets L, He C. N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell. 161, 879-92 (2015).
15. Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 55, 552-65 (2014).
14. Deng X, Liang H, Ulanovskaya OA, Ji Q, Zhou T, Sun F, Lu Z, Hutchison AL, Lan L, Wu M, Cravatt BF, He C. Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa. J Bacteriol. 196, 2499-513 (2014).
13. Chen W, Zhang L, Zheng G, Fu Y, Ji Q, Liu F, Chen H, He C. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 588, 892-8 (2014).
12. Ji Q, Zhao BS, He C. A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells. Chem Commun. 49, 8027-9 (2013).
11. Deng X, Weerapana E, Ulanovskaya O, Sun F, Liang H, Ji Q, Ye Y, Fu Y, Zhou L, Li J, Zhang H, Wang C, Alvarez S, Hicks LM, Lan L, Wu M, Cravatt BF, He C. Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host Microbe. 13, 358-70 (2013).
10. Ji Q, Zhang L, Jones MB, Sun F, Deng X, Liang H, Cho H, Brugarolas P, Gao YN, Peterson SN, Lan L, Bae T, He C. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci U S A. 110, 5010-5 (2013).
9. Liang H, Deng X, Bosscher M, Ji Q, Jensen MP, He C. Engineering bacterial two-component system PmrA/PmrB to sense lanthanide ions. J Am Chem Soc. 135, 2037-9 (2013).
8. Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L, He C. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 109, 15461-6 (2012).
7. Jeong DW, Cho H, Jones MB, Shatzkes K, Sun F, Ji Q, Liu Q, Peterson SN, He C, Bae T. The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus. Mol Microbiol. 86, 331-48 (2012).
6. Sun F, Liang H, Kong X, Xie S, Cho H, Deng X, Ji Q, Zhang H, Alvarez S, Hicks LM, Bae T, Luo C, Jiang H, He C. Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A. 109, 9095-100 (2012).
5. Ji Q, Zhang L, Sun F, Deng X, Liang H, Bae T, He C. Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response. J Biol Chem. 287, 21102-9 (2012).
4. Liang H, Deng X, Ji Q, Sun F, Shen T, He C. The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. J Bacteriol. 194, 3098-108 (2012).
3. Deng X, Sun F, Ji Q, Liang H, Missiakas D, Lan L, He C. Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus. J Bacteriol. 194, 1753-62 (2012).
2. Sun F, Ji Q, Jones MB, Deng X, Liang H, Frank B, Telser J, Peterson SN, Bae T, He C. AirSR, a
1. Ding L, Ji Q, Qian R, Cheng W, Ju H. Lectin-based nanoprobes functionalized with enzyme for highly sensitive electrochemical monitoring of dynamic carbohydrate expression on living cells. Anal Chem. 82, 1292-8 (2010).
淡忘如思 2022-05-17 19:55:13

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杂家代表人物及作品

杂家代表人物一是淮南王刘安代表作有《淮南子》,另一是编撰《吕氏春秋》的吕不韦。
杂家的特点是“采儒墨之善,撮名法之要”。杂家虽是以道为本集合众说,兼收并蓄,然而通过采集各家言论,贯彻其政治意图和学术主张,所以也可称为一家。春秋战国时代,百家争鸣,各家都有自己的对策与治国主张。为了打败其他流派,各学派或多或少的吸收其他流派的学说,或以攻诘对方,或以补自己学说的缺陷。然而,任何一个流派也都有其特色与长处,而“杂家”便是充分的利用这个特点,博采众议,成为一套在思想上兼容并蓄,却又切实可行的治国方针。
吕不韦(?—前235年),姜姓,吕氏,名不韦,卫国濮阳(今河南省安阳市滑县)人。战国末年卫国商人、政治家、思想家,后为秦国丞相,姜子牙的二十三世孙。早年经商于阳翟,将秦国质子异人带回秦国,扶植其成为秦庄襄王后,被拜为相国,封文信侯,食邑河南洛阳十万户。带兵攻取周国、赵国、卫国土地,分别设立三川郡、太原郡、东郡,对秦王嬴政兼并六国的事业作出重大贡献。庄襄王去世后,迎立太子嬴政即位,拜为相邦,尊称“仲父”,权倾天下。受到嫪毐集团叛乱牵连,罢相归国,全家流放蜀郡,途中饮鸩自尽。
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是时是什么意思

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译文:在这时,哪里知道(今天这里)会有凌虚台呢?
用法:作谓语,宾语。
近义词:此时、这时。
例句:
1、是时曹操自跟皇甫嵩讨张梁,大战于曲阳。
2、是时得诏大喜,点起军马,陆续便行。
3、是时以大中丞抚吴者为魏之私人毛一鹭,公之逮所由使也。

z=x^2+y^2是什么曲面

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曲线是x²+y²=h(h>0),平行于YOZ平面的截面。曲线是抛物线z=y²+a,平行于XOZ平面的截面。曲线是抛物线z=x²+b。
椭圆抛物面由抛物线绕其轴旋转得到的是旋转抛物面,其截面是圆形,而椭圆抛物面应该是将截面是圆形变为椭圆形,即可将旋转抛物面延径向挤压得到。
椭圆锥面与圆锥面是锥面的不同形态。椭圆锥面的方程是(x/a)²+(y/b)²-(z/c)²=0。当a=b时,即为圆锥面。

枪头是什么

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1、我手里有的枪头没开刃,是否是批量生产的结果呢?
2、只见,眼前银光一闪,刀马旦的枪头,从方为头上穿过,刀马旦的脚刚好踩在方为旁边的茶几上,飞身向观众中央而去。
3、司马俱绝望的闭上了双眼,太史慈却是将枪一摆,枪头拍在他的肩膀,强大的力量将他从马上击落在地,身后,跟上来的并州铁骑手急眼快,将其制服。